Issue 19, 2011

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Abstract

Using a ball mill, rapid, atom-economic coupling between adenosine-5′-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

Graphical abstract: Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2011
Accepted
20 Jul 2011
First published
20 Jul 2011

Org. Biomol. Chem., 2011,9, 6496-6497

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

F. Ravalico, I. Messina, M. V. Berberian, S. L. James, M. E. Migaud and J. S. Vyle, Org. Biomol. Chem., 2011, 9, 6496 DOI: 10.1039/C1OB06041D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements