Issue 19, 2011
From the journal:

Organic & Biomolecular Chemistry

Design, synthesis, and drug solubilising properties of the first folate–calix[4]arene conjugate†

Grazia M. L. Consoli,*a   Giuseppe Granataa  and  Corrada Geraci*a  

* Corresponding authors

a C.N.R. - Consiglio Nazionale delle Ricerche, Istituto di Chimica Biomolecolare, Via Paolo Gaifami 18, Catania, Italy
E-mail: grazia.consoli@icb.cnr.it
Fax: +39 095 7338310
Tel: +39 095 7338319

Abstract

The first example of a folate–calix[4]arene conjugate was designed and synthesized via microwave-assisted click chemistry. In PBS medium at physiological pH, the conjugate formed soluble aggregates and showed the capability to improve the water-solubility of a hydrophobic drug model, such as indomethacin.

Graphical abstract: Design, synthesis, and drug solubilising properties of the first folate–calix[4]arene conjugate

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Article information

DOI
https://doi.org/10.1039/C1OB06032E
Article type
Communication
Submitted
27 Jun 2011
Accepted
22 Jul 2011
First published
22 Jul 2011

Org. Biomol. Chem., 2011,9, 6491-6495

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Design, synthesis, and drug solubilising properties of the first folate–calix[4]arene conjugate

G. M. L. Consoli, G. Granata and C. Geraci, Org. Biomol. Chem., 2011, 9, 6491 DOI: 10.1039/C1OB06032E

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