Issue 15, 2011

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

Abstract

An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed. This first successful use of N-Fmoc-α-sulfo-β-alanine as a SPPS building block opens the way to the future development of promising direct “on-resin” peptide labelling and water-solubilising methods.

Graphical abstract: N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
09 May 2011
Accepted
27 May 2011
First published
27 May 2011

Org. Biomol. Chem., 2011,9, 5337-5342

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

A. Romieu, T. Bruckdorfer, G. Clavé, V. Grandclaude, C. Massif and P. Renard, Org. Biomol. Chem., 2011, 9, 5337 DOI: 10.1039/C1OB05730H

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