Issue 16, 2011

Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization

Abstract

Dinucleosides containing a thiazolidin-4-one linkage were prepared by one-pot tandem Staudinger/aza-Wittig/intermolecular cyclization under microwave irradiation and their structures were confirmed. Preliminary examination of HIV-RT inhibition showed that the dinucleosides containing (R)-thiazolidin-4-one linkage are significantly more active than those containing (S)-thiazolidin-4-one linkage.

Graphical abstract: Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization

Supplementary files

Article information

Article type
Paper
Submitted
29 Apr 2011
Accepted
16 May 2011
First published
17 May 2011

Org. Biomol. Chem., 2011,9, 5766-5772

Microwave-assisted synthesis of dinucleoside analogues containing a thiazolidin-4-one linkage via one-pot tandem Staudinger/aza-Wittig/cyclization

F. Shen, X. Li, X. Zhang, Q. Yin, Z. Qin, H. Chen, J. Zhang and Z. Ma, Org. Biomol. Chem., 2011, 9, 5766 DOI: 10.1039/C1OB05675A

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