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Issue 15, 2011
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Palladium-assisted multicomponent cyclization of aromatic aldehydes, arylamines and terminal olefins under molecular oxygen: an assembly of 1,4-dihydropyridines

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Abstract

The palladium-assisted one-pot three-component reactions of aldehydes, amines and olefins proceeded smoothly to give 2,6-unsubstituted 1,4-dihydropyridines (1,4-DHPs) using molecular oxygen as a sole oxidant. It also provides efficient Pd-catalyzed aerobic oxidation access to the anti-Markovnikov oxidative amination products of olefins from primary aromatic amines and alkenes. The method is atom-efficient, using cheap and easily available starting materials and an environmentally benign oxidant.

Graphical abstract: Palladium-assisted multicomponent cyclization of aromatic aldehydes, arylamines and terminal olefins under molecular oxygen: an assembly of 1,4-dihydropyridines

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Article information


Submitted
20 Mar 2011
Accepted
25 May 2011
First published
26 May 2011

Org. Biomol. Chem., 2011,9, 5358-5361
Article type
Communication

Palladium-assisted multicomponent cyclization of aromatic aldehydes, arylamines and terminal olefins under molecular oxygen: an assembly of 1,4-dihydropyridines

H. Jiang, X. Ji, Y. Li, Z. Chen and A. Wang, Org. Biomol. Chem., 2011, 9, 5358
DOI: 10.1039/C1OB05440F

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