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Issue 11, 2011
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Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water

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Abstract

Palladium-catalyzed N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol were carried out. The reaction in the presence of Pd(OAc)2 (5 mol%), sodium diphenylphosphinobenzene-3-sulfonate (TPPMS, 10 mol%), and AcONa (2 equiv) in water at 120 °C for 16 h in a sealed tube gave only mono-N-allylated amino acids in good yield.

Graphical abstract: Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water

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Publication details

The article was received on 15 Feb 2011, accepted on 23 Mar 2011 and first published on 24 Mar 2011


Article type: Paper
DOI: 10.1039/C1OB05238A
Org. Biomol. Chem., 2011,9, 4044-4050

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    Palladium-catalyzed mono-N-allylation of unprotected amino acids with 1,1-dimethylallyl alcohol in water

    H. Hikawa and Y. Yokoyama, Org. Biomol. Chem., 2011, 9, 4044
    DOI: 10.1039/C1OB05238A

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