Issue 11, 2011

Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

Abstract

A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.

Graphical abstract: Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

Supplementary files

Article information

Article type
Paper
Submitted
21 Jan 2011
Accepted
25 Mar 2011
First published
25 Mar 2011

Org. Biomol. Chem., 2011,9, 4250-4255

Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole

W. Chen, X. Yang, Y. Li, L. Yang, X. Wang, G. Zhang and H. Zhang, Org. Biomol. Chem., 2011, 9, 4250 DOI: 10.1039/C1OB05116D

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