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Issue 9, 2011

Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

Author affiliations

Abstract

Seven new polyoxygenated steroids, hirsutosterols A–G (1–7), were isolated from the Formosan soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configurations of 1 and 5 were determined by Mosher's method. Sterols 4–6 possess hydroxy groups at C-9 and C-11 and might be oxidatively cleaved to the corresponding 9,11-secosterols. Hirsutosterol A (1) was found to exhibit a stronger cytotoxicity against a limited panel of cancer cell lines.

Graphical abstract: Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

Supplementary files

Article information


Submitted
20 Jan 2011
Accepted
24 Feb 2011
First published
25 Feb 2011

Org. Biomol. Chem., 2011,9, 3272-3278
Article type
Paper

Hirsutosterols A–G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta

B. Chen, S. Chang, C. Huang, J. Su, Z. Wen, Y. Wu and J. Sheu, Org. Biomol. Chem., 2011, 9, 3272 DOI: 10.1039/C1OB05106G

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