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Issue 12, 2011
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Aldolase activity of serum albumins

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Abstract

Bovine and human serum albumins catalyze the aldol reaction of aromatic aldehyedes and acetone, with saturation kinetics and moderate and opposite enantioselectivity. The reaction occurs at the binding site in domain IIa, and is inhibited by warfarin. Kinetic data are consistent with an enamine mechanism. The activity is conserved in a 103 aminoacid peptide derived from the albumin sequence.

Graphical abstract: Aldolase activity of serum albumins

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Article information


Submitted
20 Dec 2010
Accepted
11 Apr 2011
First published
12 Apr 2011

Org. Biomol. Chem., 2011,9, 4417-4420
Article type
Communication

Aldolase activity of serum albumins

F. Benedetti, F. Berti and S. Bidoggia, Org. Biomol. Chem., 2011, 9, 4417
DOI: 10.1039/C0OB01219J

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