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Issue 8, 2011
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Formation and regulation of fullerene-incorporation in liposomes under the phase transition temperature

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Abstract

The fullerene-exchange reaction from a cyclodextrin cavity to liposomes represents one of the best methods to prepare lipid membrane-incorporated [70]fullerenes (C70). The C70-exchange reaction occurred completely at temperatures above the phase transition temperature (Tm) of the liposomes; however, lowering the temperature to below the Tm led to C70 aggregation outside the liposomes. This observation has limited the development of more functional LMIC70 using a variety of liposome compositions. In this paper, this reaction was found to occur efficiently by the addition of small amounts of lipids bearing a π-moiety. The π-moieties act as a gate when hydrophobic C70 migrates into the hydrophilic liposome surface. Therefore, the π-moieties should exist in the polar head groups of the lipids and the C70-exchange reaction can be controlled by pH.

Graphical abstract: Formation and regulation of fullerene-incorporation in liposomes under the phase transition temperature

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Publication details

The article was received on 16 Nov 2010, accepted on 05 Jan 2011 and first published on 15 Feb 2011


Article type: Paper
DOI: 10.1039/C0OB01030H
Org. Biomol. Chem., 2011,9, 2622-2627

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    Formation and regulation of fullerene-incorporation in liposomes under the phase transition temperature

    A. Ikeda, Y. Kawai, J. Kikuchi, M. Akiyama, E. Nakata, Y. Uto and H. Hori, Org. Biomol. Chem., 2011, 9, 2622
    DOI: 10.1039/C0OB01030H

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