Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 5, 2011
Previous Article Next Article

Tandem Blaise–Nenitzescu reaction: one-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles

Author affiliations

Abstract

In contrast to the reaction of benzoquinones with β-enaminoesters providing indoles (Nenitzescu reaction), the tandem one-pot reaction of the Blaise reaction intermediate, zinc bromide complex of β-enaminoesters, with benzoquinone affords 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones in good to excellent yields (tandem Blaise–Nenitzescu reaction).

Graphical abstract: Tandem Blaise–Nenitzescu reaction: one-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Aug 2010, accepted on 29 Nov 2010 and first published on 30 Nov 2010


Article type: Communication
DOI: 10.1039/C0OB01024C
Citation: Org. Biomol. Chem., 2011,9, 1317-1319

  •   Request permissions

    Tandem Blaise–Nenitzescu reaction: one-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles

    Y. S. Chun, K. Y. Ryu, J. H. Kim, H. Shin and S. Lee, Org. Biomol. Chem., 2011, 9, 1317
    DOI: 10.1039/C0OB01024C

Search articles by author

Spotlight

Advertisements