Issue 3, 2011
From the journal:

Organic & Biomolecular Chemistry

Stevens rearrangement as a tool for the structural modification of polyaminopolycarboxylic ligands†

Giovanni B. Giovenzana,*a   Daniela Imperio,a   Luciano Lattuadab  and  Fulvio Uggerib  

* Corresponding authors

a DiSCAFF & DFB Center, Via Bovio 6, Novara, Italy
E-mail: giovenzana@pharm.unipmn.it
Fax: +39-(0)321-375821
Tel: +39-(0)321-375846

b Bracco Imaging spa, Via Ribes 5, Colleretto Giacosa (TO), Italy

Abstract

Polyaminopolycarboxylic acids are a well known class of ligands employed for metal ion complexation. Despite the large commercial availability, reports of their use as substrates for direct structural modifications are rare. Herein we report a simple and efficient protocol for the preparation of substituted polyaminopolycarboxylic ligands relying on a one-pot N-alkylation–Stevens rearrangement cascade.

Graphical abstract: Stevens rearrangement as a tool for the structural modification of polyaminopolycarboxylic ligands

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Article information

DOI
https://doi.org/10.1039/C0OB00909A
Article type
Communication
Submitted
20 Oct 2010
Accepted
15 Nov 2010
First published
23 Nov 2010

Org. Biomol. Chem., 2011,9, 679-681

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Stevens rearrangement as a tool for the structural modification of polyaminopolycarboxylic ligands

G. B. Giovenzana, D. Imperio, L. Lattuada and F. Uggeri, Org. Biomol. Chem., 2011, 9, 679 DOI: 10.1039/C0OB00909A

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