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Issue 5, 2011
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Chemospecific and ligand free CuI catalysed heterogeneous N-arylation of amines with diheteroaryl halides at room temperature

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Abstract

A ligand free, copper-catalyzed N-arylation reaction of amines with diheteroaryl halides in heterogeneous medium at room temperature has been developed. The protocol is very effective for low boiling amines and useful for amines available in aqueous solution. The reaction gives chemospecific arylation of amines with diheteroaryl halides in the mixture monoheteroaryl halides, diheteroaryl halides and carbocyclic aryl halides. The reaction is also chemospecific with respect to arylation of aliphatic amines. Monoarylated piperazines were also synthesized at room temperature following this protocol.

Graphical abstract: Chemospecific and ligand free CuI catalysed heterogeneous N-arylation of amines with diheteroaryl halides at room temperature

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Publication details

The article was received on 10 Oct 2010, accepted on 23 Nov 2010 and first published on 24 Nov 2010


Article type: Communication
DOI: 10.1039/C0OB00859A
Citation: Org. Biomol. Chem., 2011,9, 1324-1327

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    Chemospecific and ligand free CuI catalysed heterogeneous N-arylation of amines with diheteroaryl halides at room temperature

    S. K. Verma, B. N. Acharya and M. P. Kaushik, Org. Biomol. Chem., 2011, 9, 1324
    DOI: 10.1039/C0OB00859A

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