FeCl3-promoted alkylation of indoles by enamides

Tianmin Niu; Lehao Huang; Tianxing Wu; Yuhong Zhang

doi:10.1039/C0OB00709A

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FeCl₃-promoted alkylation of indoles by enamides†

Tianmin Niu,^a Lehao Huang,^a Tianxing Wu^a and Yuhong Zhang*^a

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* Corresponding authors

^a Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China
E-mail: yhzhang@zju.edu.cn
Fax: 0086-571-87953244
Tel: 0086-571-87952723

Abstract

An efficient iron-promoted alkylation of indoles with enamides has been accomplished under mild reaction conditions. The reaction proceeded with remarkable regioselectivity leading exclusively to substitution by indoles at α-position of enamides.

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Article information

DOI: https://doi.org/10.1039/C0OB00709A
Article type: Paper
Submitted: 13 Sep 2010
Accepted: 07 Oct 2010
First published: 17 Nov 2010

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Org. Biomol. Chem., 2011,9, 273-277

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FeCl₃-promoted alkylation of indoles by enamides

T. Niu, L. Huang, T. Wu and Y. Zhang, Org. Biomol. Chem., 2011, 9, 273 DOI: 10.1039/C0OB00709A

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Organic & Biomolecular Chemistry