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Issue 6, 2011
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A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

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Abstract

An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).

Graphical abstract: A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

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Supplementary files

Article information


Submitted
04 Sep 2010
Accepted
07 Dec 2010
First published
25 Jan 2011

Org. Biomol. Chem., 2011,9, 1809-1816
Article type
Paper

A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives

Z. Jin, F. Yu, X. Wang, H. Huang, X. Luo, X. Liang and J. Ye, Org. Biomol. Chem., 2011, 9, 1809
DOI: 10.1039/C0OB00669F

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