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Issue 2, 2011
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Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: one-pot syntheses of highly functional alkenes

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Abstract

An EtPPh2- or PPh3-catalyzed tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide is developed. Its further application in one-pot syntheses of highly functional alkenes starting from aldehydes, alkyl vinyl ketones, and amides is realized. A wide variety of highly functional α,β-unsaturated ketones can be furnished in 68–99% yields with high stereoselectivity (E/Z up to 98 : 2) within overall 3–29.5 h.

Graphical abstract: Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: one-pot syntheses of highly functional alkenes

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Publication details

The article was received on 30 Aug 2010, accepted on 18 Oct 2010 and first published on 19 Oct 2010


Article type: Communication
DOI: 10.1039/C0OB00644K
Org. Biomol. Chem., 2011,9, 363-366

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    Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: one-pot syntheses of highly functional alkenes

    D. Wang, S. Syu, Y. Hung, P. Chen, C. Lee, K. Chen, Y. Chen and W. Lin, Org. Biomol. Chem., 2011, 9, 363
    DOI: 10.1039/C0OB00644K

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