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Issue 2, 2011

Synthesis of (±)-desethylrhazinal using a tandem radical addition-cyclization process

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Abstract

The indolizidine ring system present in (±)-rhazinal, was assembled using a xanthate-based sequential intermolecular radical addition-cyclization process. The novel (±)-desethylrhazinal was prepared in seven steps in approximately 12% overall yield from 2-formylpyrrole, using this strategy.

Graphical abstract: Synthesis of (±)-desethylrhazinal using a tandem radical addition-cyclization process

Supplementary files

Article information


Submitted
13 Aug 2010
Accepted
01 Oct 2010
First published
28 Oct 2010

Org. Biomol. Chem., 2011,9, 361-362
Article type
Communication

Synthesis of (±)-desethylrhazinal using a tandem radical addition-cyclization process

E. Paleo, Y. M. Osornio and L. D. Miranda, Org. Biomol. Chem., 2011, 9, 361 DOI: 10.1039/C0OB00572J

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