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Issue 22, 2010
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Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and NSacyl transfer

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Abstract

Peptide thioesters are important tools for protein synthesis and semi-synthesis through their use in Native Chemical Ligation (NCL). NCL can be employed to assemble site-specifically modified proteins that can help elucidate the mechanisms of biomolecular processes. In this article we explore the compatibility of phosphopeptide synthesis and glycopeptide synthesis with thioester production through NS acyl transfer.

Graphical abstract: Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer

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Article information


Submitted
30 Jun 2010
Accepted
09 Aug 2010
First published
09 Sep 2010

Org. Biomol. Chem., 2010,8, 5113-5119
Article type
Paper

Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and NS acyl transfer

J. Masania, J. Li, S. J. Smerdon and D. Macmillan, Org. Biomol. Chem., 2010, 8, 5113
DOI: 10.1039/C0OB00363H

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