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Issue 23, 2010

The effects of ionic liquids on azide-alkynecycloaddition reactions

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Abstract

The effect of a series of ionic liquids on the regioselectivity of the azide-alkyne cycloaddition process was investigated, demonstrating an increased selectivity for the least hindered triazole. The effects of an ionic liquid on the activation parameters for the process were determined and found to be intermediate between coordinating and non-coordinating salts. The importance of knowing the water content of the system is demonstrated by marked changes in the activation parameters in the presence of small concentrations of water.

Graphical abstract: The effects of ionic liquids on azide-alkyne cycloaddition reactions

Supplementary files

Article information


Submitted
23 Jun 2010
Accepted
23 Aug 2010
First published
24 Sep 2010

Org. Biomol. Chem., 2010,8, 5354-5358
Article type
Paper

The effects of ionic liquids on azide-alkyne cycloaddition reactions

S. R. D. George, G. L. Edwards and J. B. Harper, Org. Biomol. Chem., 2010, 8, 5354 DOI: 10.1039/C0OB00306A

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