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Issue 17, 2010
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Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

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Abstract

An 88 member library based upon the marine bacterial metabolite ethyl N-(2-phenethyl) carbamate was evaluated for bacterial biofilm inhibition against a panel of medically relevant strains. These studies culminated in the discovery of a new class of molecules capable of inhibiting the formation of S. aureus biofilms with low micromolar IC50 values.

Graphical abstract: Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

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Publication details

The article was received on 29 Apr 2010, accepted on 09 Jun 2010 and first published on 08 Jul 2010


Article type: Communication
DOI: 10.1039/C0OB00063A
Org. Biomol. Chem., 2010,8, 3857-3859

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    Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

    S. A. Rogers, D. C. Whitehead, T. Mullikin and C. Melander, Org. Biomol. Chem., 2010, 8, 3857
    DOI: 10.1039/C0OB00063A

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