Issue 16, 2010
From the journal:

Organic & Biomolecular Chemistry

Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate†

Elisa Fasani,*a   Ilse Manet,b   Massimo L. Capobianco,b   Sandra Monti,*b   Luca Pretalia  and  Angelo Albini*a  

* Corresponding authors

a Dip. Chimica Organica, Università di Pavia, viale Taramelli 10, Italy
E-mail: angelo.albini@unipv.it
Fax: 39 0382 987323
Tel: 39 0382 987316

b ISOF-CNR, via Gobetti 101, 40129 Bologna, Italy
E-mail: monti@isof.cnr.it
Fax: 39 0516399844
Tel: 39 0516399813

Abstract

The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (kr > 109 M−1s−1) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy

Graphical abstract: Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

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Article information

DOI
https://doi.org/10.1039/C0OB00056F
Article type
Communication
Submitted
28 Apr 2010
Accepted
09 Jun 2010
First published
23 Jun 2010

Org. Biomol. Chem., 2010,8, 3621-3623

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Fluoroquinolones as potential photochemotherapeutic agents: covalent addition to guanosine monophosphate

E. Fasani, I. Manet, M. L. Capobianco, S. Monti, L. Pretali and A. Albini, Org. Biomol. Chem., 2010, 8, 3621 DOI: 10.1039/C0OB00056F

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