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Issue 17, 2010
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Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptorantagonists or agonists

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Abstract

The synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave assisted 1,3-dipolar cycloaddition as key step is described. The binding on membranes of cells that over express A1 adenosine receptors (A1AR) was also evaluated. Among them, four compounds increased cAMP production, in a dose-dependent manner acting as antagonists of the A1AR, while two compounds act as agonists.

Graphical abstract: Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

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Article information


Submitted
19 Apr 2010
Accepted
11 Jun 2010
First published
09 Jul 2010

Org. Biomol. Chem., 2010,8, 3874-3881
Article type
Paper

Expeditious synthesis and biological evaluation of new C-6 1,2,3-triazole adenosine derivatives A1 receptor antagonists or agonists

S. C. Mathew, Y. By, A. Berthault, M. Virolleaud, L. Carrega, G. Chouraqui, L. Commeiras, J. Condo, M. Attolini, A. Gaudel-Siri, J. Ruf, J. Rodriguez, J. Parrain and R. Guieu, Org. Biomol. Chem., 2010, 8, 3874
DOI: 10.1039/C0OB00017E

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