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Issue 19, 2010
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Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

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Abstract

Three methods are utilized to synthesize a variety of 6,8-di-C-glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-α expression and NO production with IC50 values of 6.8 and 5.2 μM, respectively.

Graphical abstract: Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

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Supplementary files

Article information


Submitted
16 Apr 2010
Accepted
28 Jun 2010
First published
19 Aug 2010

Org. Biomol. Chem., 2010,8, 4451-4462
Article type
Paper

Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities

J. Shie, C. Chen, C. Lin, A. F. Ku, T. R. Cheng, J. Fang and C. Wong, Org. Biomol. Chem., 2010, 8, 4451
DOI: 10.1039/C0OB00011F

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