Issue 16, 2010
From the journal:

Organic & Biomolecular Chemistry

Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogenins†‡

Chia-Hsiu Chen,a   Ting-Chun Kuan,a   Ke-Jhen Lua  and  Duen-Ren Hou*a  

* Corresponding authors

a Department of Chemistry, National Central University, 300 Jhong-Da Rd., Jhong-Li, Taoyuan, Taiwan
E-mail: drhou@ncu.edu.tw
Fax: 886-3-4227664
Tel: 886-3-4227151 ext. 65981

Abstract

The bis-THF cores of annonaceous acetogenins were synthesized using (3R,4R)-1,5-hexadiene-3,4-diol (1) as the sole source of carbon atoms. The methylene acetal function was applied as a new linker/tether to facilitate the ring-closing metathesis.

Graphical abstract: Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogenins

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Article information

DOI
https://doi.org/10.1039/C004672H
Article type
Communication
Submitted
25 Mar 2010
Accepted
17 Jun 2010
First published
30 Jun 2010

Org. Biomol. Chem., 2010,8, 3624-3626

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Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogenins

C. Chen, T. Kuan, K. Lu and D. Hou, Org. Biomol. Chem., 2010, 8, 3624 DOI: 10.1039/C004672H

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