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Issue 17, 2010
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Enhanced drug loading in polymerized micellar cargo

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Abstract

A new drug carrier system based on self-assembly and polymerization of polydiacetylenic amphiphiles is described. Although classical amphiphiles can help in solubilizing hydrophobic molecules upon self-arrangement into a variety of nanometric structures, a greater effect on drug loading was observed for our polymerized micelles as compared to the non-polymerized analogues. This permitted higher aqueous solubilization of lipophilic drugs with low micelle concentration. 14C labeling of a model drug on one side and of the amphiphile on the other side permitted assessment, after intravenous injection, of biodistribution and excretion profiles of the drug cargo.

Graphical abstract: Enhanced drug loading in polymerized micellar cargo

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Publication details

The article was received on 15 Mar 2010, accepted on 10 Jun 2010 and first published on 09 Jul 2010


Article type: Paper
DOI: 10.1039/C004134C
Org. Biomol. Chem., 2010,8, 3902-3907

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    Enhanced drug loading in polymerized micellar cargo

    J. Ogier, T. Arnauld, G. Carrot, A. Lhumeau, J. Delbos, C. Boursier, O. Loreau, F. Lefoulon and E. Doris, Org. Biomol. Chem., 2010, 8, 3902
    DOI: 10.1039/C004134C

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