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Issue 11, 2010
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An efficient entry to 1,2-benzisoxazoles via1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

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Abstract

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

Graphical abstract: An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

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Article information


Submitted
05 Jan 2010
Accepted
09 Mar 2010
First published
07 Apr 2010

Org. Biomol. Chem., 2010,8, 2537-2542
Article type
Paper

An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

C. Spiteri, C. Mason, F. Zhang, D. J. Ritson, P. Sharma, S. Keeling and J. E. Moses, Org. Biomol. Chem., 2010, 8, 2537
DOI: 10.1039/B927235F

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