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Issue 8, 2010
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Structure elucidation and spectroscopic analysis of photodegradants of the anti-rhinitis drug fluticasone furoate

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Abstract

Fluticasone furoate is a novel glucocorticoid receptor agonist marketed as a treatment for seasonal and perennial allergic rhinitis. Forced degradation of fluticasone furoate under conditions of light led to a number of degradation products, the structures of which were elucidated using mass spectrometry and a range of one and two-dimensional NMR experiments. Three structures were derived, including two which involved a rearrangement of the steroid ring A to give cross-linked degradation products. The results demonstrate the applicability of a previously observed mechanism of photodegradation to fluticasone furoate.

Graphical abstract: Structure elucidation and spectroscopic analysis of photodegradants of the anti-rhinitis drug fluticasone furoate

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Article information


Submitted
23 Dec 2009
Accepted
09 Feb 2010
First published
05 Mar 2010

Org. Biomol. Chem., 2010,8, 1876-1880
Article type
Paper

Structure elucidation and spectroscopic analysis of photodegradants of the anti-rhinitis drug fluticasone furoate

B. Bardsley, M. S. Smith and B. H. Gibbon, Org. Biomol. Chem., 2010, 8, 1876
DOI: 10.1039/B926964A

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