Issue 10, 2010
From the journal:

Organic & Biomolecular Chemistry

Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex†

Bo-Wei Chen,a   Chih-Hua Chao,a   Jui-Hsin Su,b   Zhi-Hong Wen,a   Ping-Jyun Sungc  and  Jyh-Horng Sheu*ad  

* Corresponding authors

a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan

b Department of Biological Science and Technology, Mei-Ho Institute of Technology, 23 Ping Kuang Road, Neipu Hsiang, Pingtung 912, Taiwan

c Taiwan Coral Research Center, National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan

d Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan

Abstract

Three novel eunicellin-based diterpenoids, namely klysimplexin sulfoxides A–C (1–3), were isolated from the cultured soft coral Klyxum simplex. Their structures were elucidated by spectroscopic methods, particularly 1D and 2D-NMR experiments. Compounds 1–3 significantly inhibited the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells.

Graphical abstract: Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

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Article information

DOI
https://doi.org/10.1039/B926353E
Article type
Paper
Submitted
16 Dec 2009
Accepted
05 Mar 2010
First published
16 Mar 2010

Org. Biomol. Chem., 2010,8, 2363-2366

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Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex

B. Chen, C. Chao, J. Su, Z. Wen, P. Sung and J. Sheu, Org. Biomol. Chem., 2010, 8, 2363 DOI: 10.1039/B926353E

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