Issue 7, 2010
From the journal:

Organic & Biomolecular Chemistry

Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli†

Barbara Rohm,a   Kirstin Scherlacha  and  Christian Hertweck*ab  

* Corresponding authors

a Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, D-07745 Jena, Germany
E-mail: Christian.Hertweck@hki-jena.de
Fax: + 49 3641 5320804
Tel: + 49 3641 5321100

b Friedrich Schiller University, Jena, Germany

Abstract

Biosynthetic studies with 13C-labelled acetates and methionine revealed that the infamous, food-related toxin bongkrekic acid from Burkholderia gladioli is a polyketide with acetate-derived β-branches and a carboxylate terminus derived from the methyl group of an acetate.

Graphical abstract: Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli

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Article information

DOI
https://doi.org/10.1039/B925483H
Article type
Communication
Submitted
03 Dec 2009
Accepted
18 Jan 2010
First published
05 Feb 2010

Org. Biomol. Chem., 2010,8, 1520-1522

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Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli

B. Rohm, K. Scherlach and C. Hertweck, Org. Biomol. Chem., 2010, 8, 1520 DOI: 10.1039/B925483H

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