Issue 4, 2010

A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

Abstract

Homoenolate generated from α,β-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.

Graphical abstract: A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

Supplementary files

Article information

Article type
Communication
Submitted
21 Jul 2009
Accepted
17 Dec 2009
First published
06 Jan 2010

Org. Biomol. Chem., 2010,8, 761-764

A novel pseudo four component reaction involving homoenolate for the synthesis of γ-aminobutyric acid (GABA) derivatives

V. Nair, V. Varghese, B. P. Babu, C. R. Sinu and E. Suresh, Org. Biomol. Chem., 2010, 8, 761 DOI: 10.1039/B922981G

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