Issue 5, 2010
From the journal:

Organic & Biomolecular Chemistry

BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins†‡

Cristina Rodríguez,a   Gonzalo de Gonzalo,a   Ana Rioz-Martínez,a   Daniel E. Torres Pazmiño,b   Marco W. Fraaijeb  and  Vicente Gotor*a  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, Oviedo, Spain
E-mail: vgs@fq.uniovi.es
Fax: (+34) 985 103448
Tel: (+34) 985 103448

b Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 4, Groningen, AG, The Netherlands

Abstract

4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer–Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.

Graphical abstract: BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

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Article information

DOI
https://doi.org/10.1039/B922693A
Article type
Paper
Submitted
30 Oct 2009
Accepted
30 Nov 2009
First published
07 Jan 2010

Org. Biomol. Chem., 2010,8, 1121-1125

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BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins

C. Rodríguez, G. de Gonzalo, A. Rioz-Martínez, D. E. Torres Pazmiño, M. W. Fraaije and V. Gotor, Org. Biomol. Chem., 2010, 8, 1121 DOI: 10.1039/B922693A

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