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Issue 7, 2010
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Triple molecular target approach to selective melanoma cytotoxicity

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Abstract

Phenylalanine-linked pyrrolo[1,2-a]benzimidazoles were successfully designed to target melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump, the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of these compounds as well as the results of in vitro, in vivo, and QSAR studies.

Graphical abstract: Triple molecular target approach to selective melanoma cytotoxicity

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Publication details

The article was received on 29 Sep 2009, accepted on 21 Dec 2009 and first published on 28 Jan 2010


Article type: Paper
DOI: 10.1039/B920260A
Org. Biomol. Chem., 2010,8, 1577-1587

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    Triple molecular target approach to selective melanoma cytotoxicity

    E. B. Skibo, A. Jamil, B. Austin, D. Hansen and A. Ghodousi, Org. Biomol. Chem., 2010, 8, 1577
    DOI: 10.1039/B920260A

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