Triple molecular target approach to selective melanoma cytotoxicity

Edward B. Skibo; Akmal Jamil; Brittany Austin; Douglas Hansen; Armand Ghodousi

doi:10.1039/B920260A

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Triple molecular target approach to selective melanoma cytotoxicity†

Edward B. Skibo,*^a Akmal Jamil,^a Brittany Austin,^a Douglas Hansen^a and Armand Ghodousi^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-1604
E-mail: eskibo@asu.edu
Fax: +1 480 965 2747
Tel: +1 480 965 3581

Abstract

Phenylalanine-linked pyrrolo[1,2-a]benzimidazoles were successfully designed to target melanoma cells in vitro. Our design utilised three molecular targets: a phenylalanine pump, the reducing enzyme DT-diaphorase, and IMP dehydrogenase. We describe the synthesis of these compounds as well as the results of in vitro, in vivo, and QSAR studies.

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Supplementary files

Spectroscopic data for all compounds and in vitro assay results PDF (4300K)

Article information

DOI: https://doi.org/10.1039/B920260A
Article type: Paper
Submitted: 29 Sep 2009
Accepted: 21 Dec 2009
First published: 28 Jan 2010

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Org. Biomol. Chem., 2010,8, 1577-1587

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Triple molecular target approach to selective melanoma cytotoxicity

E. B. Skibo, A. Jamil, B. Austin, D. Hansen and A. Ghodousi, Org. Biomol. Chem., 2010, 8, 1577 DOI: 10.1039/B920260A

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Organic & Biomolecular Chemistry

Triple molecular target approach to selective melanoma cytotoxicity†

Abstract

Supplementary files

Article information

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Triple molecular target approach to selective melanoma cytotoxicity

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