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Issue 6, 2010
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Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

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Abstract

Elimination of suitable leaving groups from 3-substituted indoles under basic or acidic conditions readily provides alkylideneindolenine intermediates that may react with a large variety of nucleophilic reagents. This article highlights some recent developments of this synthetic approach for the preparation of functionalized indole derivatives.

Graphical abstract: Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

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Article information


Submitted
24 Sep 2009
Accepted
13 Nov 2009
First published
16 Dec 2009

Org. Biomol. Chem., 2010,8, 1259-1270
Article type
Perspective

Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates

A. Palmieri, M. Petrini and R. R. Shaikh, Org. Biomol. Chem., 2010, 8, 1259 DOI: 10.1039/B919891A

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