Facile preparation of CF3-substituted carbinols with an azine donor and subsequent kinetic resolution through stereoselective Si–O coupling

Abstract

A number of CF₃-substituted carbinols decorated with an azine donor are efficiently prepared from fluoral and kinetically resolved in a reagent-controlled, Cu–H-catalysed Si–O coupling with a chiral silane. Selectivity factors are high, indicating a larger steric effect than CH₃ or C₆H₅groups.