Issue 21, 2009
From the journal:

Organic & Biomolecular Chemistry

3,5-Isoxazoles from α-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides†

Chieh Chien Lee,a   Richard J. Fitzmauricea  and  Stephen Caddick*a  

* Corresponding authors

a Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gordon Street, London, UK

Abstract

The regioselective 1,3-dipolar cycloaddition of α-bromo-pentafluorophenyl vinylsulfonate with nitrile oxides has been used to rapidly access a range of 3,5-isoxazoles which could be converted directly to their corresponding sulfonamides.

Graphical abstract: 3,5-Isoxazoles from α-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides

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Article information

DOI
https://doi.org/10.1039/B911098D
Article type
Communication
Submitted
05 Jun 2009
Accepted
10 Aug 2009
First published
25 Aug 2009

Org. Biomol. Chem., 2009,7, 4349-4351

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3,5-Isoxazoles from α-bromo-pentafluorophenyl vinylsulfonates: Synthesis of sulfonates and sulfonamides

C. C. Lee, R. J. Fitzmaurice and S. Caddick, Org. Biomol. Chem., 2009, 7, 4349 DOI: 10.1039/B911098D

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