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Issue 17, 2009
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High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations

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Abstract

An efficient amine-/ruthenium-catalyzed three-step process for the synthesis of Nefopam analogues was achieved through combinations of cascade enamine amination/iso-aromatization/allylation and diene or enyne metathesis as key steps starting from functionalized Hagemann's esters. In this communication, we discovered the application of ruthenium-catalysis on olefins containing free amines without in situ formation of salts.

Graphical abstract: High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations

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Publication details

The article was received on 27 May 2009, accepted on 23 Jun 2009 and first published on 03 Jul 2009


Article type: Communication
DOI: 10.1039/B910397J
Citation: Org. Biomol. Chem., 2009,7, 3372-3378

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    High-yielding synthesis of Nefopam analogues (functionalized benzoxazocines) by sequential one-pot cascade operations

    D. B. Ramachary, V. V. Narayana, M. S. Prasad and K. Ramakumar, Org. Biomol. Chem., 2009, 7, 3372
    DOI: 10.1039/B910397J

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