Issue 14, 2009
From the journal:

Organic & Biomolecular Chemistry

Recent highlights in the synthesis of highly functionalized pyrimidines

Marco Radi,a   Silvia Schenoneb  and  Maurizio Botta*ac  

* Corresponding authors

a Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Alcide de Gasperi 2, Siena, Italy
E-mail: botta@unisi.it
Fax: +39 0577 234333
Tel: +39 0577 234306

b Dipartimento di Scienze Farmaceutiche, Università degli Studi di Genova, Viale Benedetto XV, Genova, Italy

c Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg., Suite 333, 1900 N 12th Street, Philadelphia, PA, US

Abstract

The pyrimidine scaffold represents an important pharmacophore endowed with a wide range of pharmacological activities according to the specific decoration of the heterocycle. This perspective article will briefly outline the most interesting approaches recently reported for the synthesis of highly functionalized pyrimidine derivatives.

Graphical abstract: Recent highlights in the synthesis of highly functionalized pyrimidines

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Article information

DOI
https://doi.org/10.1039/B906445A
Article type
Perspective
Submitted
02 Apr 2009
First published
12 Jun 2009

Org. Biomol. Chem., 2009,7, 2841-2847

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Recent highlights in the synthesis of highly functionalized pyrimidines

M. Radi, S. Schenone and M. Botta, Org. Biomol. Chem., 2009, 7, 2841 DOI: 10.1039/B906445A

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