Issue 5, 2009
From the journal:

Organic & Biomolecular Chemistry

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

Teather J. Sundstrom,a   Amy C. Andersona  and  Dennis L. Wright*a  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, U-3092, Storrs, U. S. A.

Abstract

Phosphoinositide-3-kinase is a pivotal protein involved in a wide variety of signaling cascades and there has been a great deal of interest in the development of potent and selective inhibitors of this enzyme. In this review, the potency and selectivity of the known inhibitors is presented along with key structural information that helps rationalize the observed trends.

Graphical abstract: Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

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Article information

DOI
https://doi.org/10.1039/B819067B
Article type
Perspective
Submitted
27 Oct 2008
Accepted
24 Nov 2008
First published
08 Jan 2009

Org. Biomol. Chem., 2009,7, 840-850

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Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

T. J. Sundstrom, A. C. Anderson and D. L. Wright, Org. Biomol. Chem., 2009, 7, 840 DOI: 10.1039/B819067B

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