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Issue 19, 2008
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Organocatalytic asymmetric ring-opening of aziridines

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Abstract

The organocatalytic ring-opening of N-tosyl protected aziridines by β-ketoesters under chiral PTC-conditions, leading to the formation of optically active aminoethyl functionalised compounds with up to 99% ee, has been developed.

Graphical abstract: Organocatalytic asymmetric ring-opening of aziridines

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Article information


Submitted
18 Jul 2008
Accepted
06 Aug 2008
First published
20 Aug 2008

Org. Biomol. Chem., 2008,6, 3467-3470
Article type
Communication

Organocatalytic asymmetric ring-opening of aziridines

M. W. Paixão, M. Nielsen, C. B. Jacobsen and K. A. Jørgensen, Org. Biomol. Chem., 2008, 6, 3467
DOI: 10.1039/B812369A

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