Jump to main content
Jump to site search

Issue 19, 2008
Previous Article Next Article

Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

Author affiliations

Abstract

γ-Turn analogues comprising a modified dipeptide constrained in an eleven-membered ring were prepared by alkene metathesis and analysed by NMR and molecular modelling studies. The results reveal that some of the cyclic analogues form inverse γ-turns and preferentially adopt conformations determined by the identity of the incorporated amino acid residues and the nature of the constraining linker (E/Z-alkene or alkane).

Graphical abstract: Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

Back to tab navigation

Supplementary files

Article information


Submitted
28 May 2008
Accepted
04 Jul 2008
First published
07 Aug 2008

Org. Biomol. Chem., 2008,6, 3476-3485
Article type
Paper

Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

M. Kaewpet, B. Odell, M. A. King, B. Banerji, C. J. Schofield and T. D. W. Claridge, Org. Biomol. Chem., 2008, 6, 3476
DOI: 10.1039/B808954J

Social activity

Search articles by author

Spotlight

Advertisements