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Issue 19, 2008
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Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

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Abstract

A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.

Graphical abstract: Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

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Article information


Submitted
06 May 2008
Accepted
25 Jul 2008
First published
19 Aug 2008

Org. Biomol. Chem., 2008,6, 3464-3466
Article type
Communication

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

M. G. Pizzuti, A. J. Minnaard and B. L. Feringa, Org. Biomol. Chem., 2008, 6, 3464 DOI: 10.1039/B807575A

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