Issue 17, 2008
From the journal:

Organic & Biomolecular Chemistry

Synthesis and in vitro evaluation of imidazole-based wakayin analogues

Hung Hoang,a   Xiaofen Huanga  and  Edward B. Skibo*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona
E-mail: eskibo@asu.edu
Fax: 480 965 2747
Tel: 480 965 3581

Abstract

Analogues of wakayin based on diimidazo[1,5,4-de, 1,5,4-h]-quinoxaline have been prepared and evaluated with respect to cytostatic and cytotoxic activity. Assays in a 60-cell-line human cancer panel revealed selective activity against cells with the VEGF (Flt-1) receptor.

Graphical abstract: Synthesis and in vitro evaluation of imidazole-based wakayin analogues

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Article information

DOI
https://doi.org/10.1039/B806883F
Article type
Paper
Submitted
25 Apr 2008
Accepted
01 Jul 2008
First published
16 Jul 2008

Org. Biomol. Chem., 2008,6, 3059-3064

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Synthesis and in vitro evaluation of imidazole-based wakayin analogues

H. Hoang, X. Huang and E. B. Skibo, Org. Biomol. Chem., 2008, 6, 3059 DOI: 10.1039/B806883F

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