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Issue 12, 2008
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A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

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Abstract

A novel and effective organocatalytic system consisting of pyrrolidinyl-thioimidazole and a chiral thioureido acid efficiently catalyzed the asymmetric Michael addition reactions of ketones to nitroolefins to afford the adducts with high diastereoselectivities (up to 99 : 1) and excellent enantioselectivities (up to 99% ee).

Graphical abstract: A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

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Publication details

The article was received on 17 Mar 2008, accepted on 22 Apr 2008 and first published on 16 May 2008


Article type: Communication
DOI: 10.1039/B804541K
Org. Biomol. Chem., 2008,6, 2054-2057

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    A chiral thioureido acid as an effective additive for enantioselective organocatalytic Michael additions of nitroolefins

    D. Xu, H. Yue, S. Luo, A. Xia, S. Zhang and Z. Xu, Org. Biomol. Chem., 2008, 6, 2054
    DOI: 10.1039/B804541K

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