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Issue 9, 2008
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The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

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[2.2]Paracyclophane is a fascinating molecule that offers great potential in a wide range of chemical disciplines. Currently, the synthesis of the majority of enantiomerically pure [2.2]paracyclophane derivatives is based on the resolution of a small number of starting materials or individual resolution procedures are developed for each new compound. The development of more general routes to these valuable compounds via the resolution of a common intermediate is discussed. Ultimately, it would be preferable to synthesise these valuable compounds without recourse to resolution and ideas for this rewarding goal are postulated.

Graphical abstract: The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

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Publication details

The article was received on 14 Jan 2008, accepted on 25 Feb 2008 and first published on 19 Mar 2008

Article type: Emerging Area
DOI: 10.1039/B800698A
Org. Biomol. Chem., 2008,6, 1527-1534

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    The synthesis of enantiomerically pure [2.2]paracyclophane derivatives

    G. J. Rowlands, Org. Biomol. Chem., 2008, 6, 1527
    DOI: 10.1039/B800698A

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