Issue 7, 2008

Approach to the hyacinthacines: first non-chiral pool synthesis of (+)-hyacinthacine A1

Abstract

The first non-chiral pool total synthesis of (+)-hyacinthacine A1 is described. This synthesis is based on an effective [2 + 2] cycloaddition of dichloroketene to a Stericol®-based enol ether, a diastereoselective dihydroxylation, and an efficient Tamao–Fleming oxidation.

Graphical abstract: Approach to the hyacinthacines: first non-chiral pool synthesis of (+)-hyacinthacine A1

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2008
Accepted
15 Feb 2008
First published
28 Feb 2008

Org. Biomol. Chem., 2008,6, 1170-1172

Approach to the hyacinthacines: first non-chiral pool synthesis of (+)-hyacinthacine A1

P. V. Reddy, A. Veyron, P. Koos, A. Bayle, A. E. Greene and P. Delair, Org. Biomol. Chem., 2008, 6, 1170 DOI: 10.1039/B800445E

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