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Issue 8, 2008
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Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

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Abstract

The marine alkaloid oroidin along with a small library of reverse amide (RA) 2-aminoimidazoles were synthesized and assayed for anti-biofilm activity against PAO1 and PA14, two strains of the medically relevant γ-proteobacteriumPseudomonas aeruginosa. Analogues that contained a long, linear alkyl chain were more potent inhibitors than the natural product at preventing the formation of PAO1 and PA14 biofilms. The most active compound in the series was also shown to disperse established PAO1 and PA14 biofilms at low micromolar concentrations.

Graphical abstract: Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

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Supplementary files

Article information


Submitted
11 Dec 2007
Accepted
31 Jan 2008
First published
05 Mar 2008

Org. Biomol. Chem., 2008,6, 1356-1363
Article type
Paper

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

J. J. Richards, T. E. Ballard and C. Melander, Org. Biomol. Chem., 2008, 6, 1356
DOI: 10.1039/B719082D

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