Issue 8, 2008

Stereoselective synthesis of (+)-polyoxamic acid based on the synthesis of chiral oxazine

Abstract

A concise, stereocontrolled synthesis of (+)-polyoxamic acid was achieved. Starting from trans-oxazoline as a chiral building block, the key step involves diastereoselective oxazine formation catalyzed by palladium(0).

Graphical abstract: Stereoselective synthesis of (+)-polyoxamic acid based on the synthesis of chiral oxazine

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2007
Accepted
28 Jan 2008
First published
06 Mar 2008

Org. Biomol. Chem., 2008,6, 1498-1501

Stereoselective synthesis of (+)-polyoxamic acid based on the synthesis of chiral oxazine

J. Joo, V. Pham, Y. Tian, Y. Chung, C. Oh, K. Lee and W. Ham, Org. Biomol. Chem., 2008, 6, 1498 DOI: 10.1039/B717961H

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