Issue 4, 2008
From the journal:

Organic & Biomolecular Chemistry

On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles

Stefano Chimichi,*a   Marco Boccalini,*a   Silvia Selleri,b   Camilla Costagli,b   Gabriella Guerrinib  and  Giampietro Violac  

* Corresponding authors

a Dipartimento di Chimica Organica “U. Schiff” and Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi (HeteroBioLab), University of Florence, via della Lastruccia 13, I 50019 Sesto F.no (Firenze), Italy
E-mail: stefano.chimichi@unifi.it
Fax: +39 055 4573568
Tel: +39 055 4573537

b Dipartimento di Scienze Farmaceutiche, University of Florence, via U. Schiff 6, I-50019 Sesto F.no (Firenze), Italy

c Dipartimento di Scienze Farmaceutiche, University of Padova, via Marzolo 5, I 35131 Padova, Italy

Abstract

Reaction of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidine 1 with 1,3- and 1,4-bisnucleophiles has been investigated; obtainment of new polycyclic heterocyclic derivatives is reported. A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained.

Graphical abstract: On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles

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Article information

DOI
https://doi.org/10.1039/B717835B
Article type
Paper
Submitted
19 Nov 2007
Accepted
13 Dec 2007
First published
14 Jan 2008

Org. Biomol. Chem., 2008,6, 739-744

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On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles

S. Chimichi, M. Boccalini, S. Selleri, C. Costagli, G. Guerrini and G. Viola, Org. Biomol. Chem., 2008, 6, 739 DOI: 10.1039/B717835B

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