Issue 1, 2008

Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

Abstract

Phenothiazine can be incorporated as a redox-active probe into DNA in two conceptually different ways: the non-nucleosidic DNA base surrogate exhibits similar properties to 10-methylphenothiazine but with no preferential base-pairing properties, whereas the phenothiazine-modified uridine has different optical and electrochemical properties, but exhibits preferred Watson–Crick base pairing with adenine.

Graphical abstract: Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

Supplementary files

Article information

Article type
Communication
Submitted
12 Jun 2007
Accepted
22 Oct 2007
First published
31 Oct 2007

Org. Biomol. Chem., 2008,6, 48-50

Phenothiazine as a redox-active DNA base substitute: comparison with phenothiazine-modified uridine

C. Wagner and H. Wagenknecht, Org. Biomol. Chem., 2008, 6, 48 DOI: 10.1039/B708904J

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