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Issue 22, 2007
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Design and synthesis of α-helical peptides and mimetics

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Abstract

The α-helix is the most abundant secondary structural element in proteins and is an important structural domain for mediating proteinprotein and protein–nucleic acid interactions. Strategies for the rational design and synthesis of α-helix mimetics have not matured as well as other secondary structure mimetics such as strands and turns. This perspective will focus on developments in the design, synthesis and applications of α-helices and mimetics, particularly in the last 5 years. Examples where synthetic compounds have delivered promising biological results will be highlighted as well as opportunities for the design of mimetics of the type I α-helical antifreeze proteins.

Graphical abstract: Design and synthesis of α-helical peptides and mimetics

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Publication details

The article was received on 09 Jul 2007 and first published on 07 Sep 2007


Article type: Perspective
DOI: 10.1039/B710425A
Org. Biomol. Chem., 2007,5, 3577-3585

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    Design and synthesis of α-helical peptides and mimetics

    J. Garner and M. M. Harding, Org. Biomol. Chem., 2007, 5, 3577
    DOI: 10.1039/B710425A

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